San Francisco 49ersSF · 2026 SCHEDULE

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WEEK 1  THU SEP 10  8:35 PM ET  (neutral)
  AWAY @ Los Angeles RamsLAR
  SCORE W 27-7
  LINE  --    O/U --
  WX    --
  TV    NFLX

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WEEK 2  SUN SEP 20  4:25 PM ET
  HOME vs Miami DolphinsMIA
  SCORE W 35-13
  LINE  --    O/U --
  WX    --
  TV    FOX

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WEEK 3  SUN SEP 27  4:05 PM ET
  HOME vs Arizona CardinalsARI
  SCORE W 36-30
  LINE  --    O/U --
  WX    --
  TV    FOX

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WEEK 4  SUN OCT 4  4:25 PM ET
  HOME vs Denver BroncosDEN
  LINE  SF -3    O/U 46.5
  WX    83°F Sunny
  TV    CBS

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WEEK 5  SUN OCT 11  4:25 PM ET
  AWAY @ Seattle SeahawksSEA
  LINE  SEA -3.5    O/U 48.5
  WX    --
  TV    FOX

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WEEK 6  MON OCT 19  8:15 PM ET
  HOME vs Washington CommandersWSH
  LINE  SF -5.5    O/U 50.5
  WX    --
  TV    ESPN, ABC

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WEEK 7  SUN OCT 25  1:00 PM ET
  AWAY @ Atlanta FalconsATL
  LINE  SF -4.5    O/U 47.5
  WX    Indoors
  TV    FOX

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WEEK 8
  BYE

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WEEK 9  SUN NOV 8  4:05 PM ET
  HOME vs Las Vegas RaidersLV
  LINE  SF -8.5    O/U 46.5
  WX    --
  TV    CBS

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WEEK 10  SUN NOV 15  4:25 PM ET
  AWAY @ Dallas CowboysDAL
  LINE  DAL -1.5    O/U 52.5
  WX    Indoors
  TV    FOX

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WEEK 11  SUN NOV 22  8:20 PM ET  (neutral)
  HOME vs Minnesota VikingsMIN
  LINE  SF -3.5    O/U 46.5
  WX    --
  TV    NBC

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WEEK 12  SUN NOV 29  4:25 PM ET
  HOME vs Seattle SeahawksSEA
  LINE  SEA -1.5    O/U 46.5
  WX    --
  TV    FOX

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WEEK 13  SUN DEC 6  1:00 PM ET
  AWAY @ New York GiantsNYG
  LINE  SF -3    O/U 47.5
  WX    --
  TV    FOX

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WEEK 14  SUN DEC 13  4:25 PM ET
  HOME vs Los Angeles RamsLAR
  LINE  LAR -1.5    O/U 49.5
  WX    --
  TV    FOX

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WEEK 15  THU DEC 17  8:15 PM ET
  AWAY @ Los Angeles ChargersLAC
  LINE  LAC -2.5    O/U 47.5
  WX    --
  TV    PRIME

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WEEK 16  SUN DEC 27  4:25 PM ET
  AWAY @ Kansas City ChiefsKC
  LINE  KC -3    O/U 46.5
  WX    --
  TV    CBS

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WEEK 17  SUN JAN 3  8:20 PM ET
  HOME vs Philadelphia EaglesPHI
  LINE  SF -1.5    O/U 45.5
  WX    --
  TV    NBC

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WEEK 18  SUN JAN 10  TBD ET
  AWAY @ Arizona CardinalsARI
  LINE  SF -8.5    O/U 44.5
  WX    Indoors
  TV    --

Odds via ESPN. Updated 9/29/2026, 3:30:21 PM ET